مامایی و بارداری
مقالهها، منابع و پژوهشهای تازه حوزه مامایی و بارداری
ورود به زیرشاخهنقشه موضوعی
جستوجوی دقیقزنان، زایمان و کودکان
سلامت مادر، جنین، نوزاد، کودک و نوجوان
زیرشاخهها
برای رسیدن به فهرست متمرکزتر، یک مسیر تخصصی را انتخاب کنید.
بیماریهای زنان
مقالهها، منابع و پژوهشهای تازه حوزه بیماریهای زنان
ورود به زیرشاخهپزشکی تولیدمثل و ناباروری
مقالهها، منابع و پژوهشهای تازه حوزه پزشکی تولیدمثل و ناباروری
ورود به زیرشاخهطب مادر و جنین
مقالهها، منابع و پژوهشهای تازه حوزه طب مادر و جنین
ورود به زیرشاخهنوزادان
مقالهها، منابع و پژوهشهای تازه حوزه نوزادان
ورود به زیرشاخهکودکان
مقالهها، منابع و پژوهشهای تازه حوزه کودکان
ورود به زیرشاخهطب نوجوانان
مقالهها، منابع و پژوهشهای تازه حوزه طب نوجوانان
ورود به زیرشاخهجراحی کودکان
مقالهها، منابع و پژوهشهای تازه حوزه جراحی کودکان
ورود به زیرشاخهتازهترین رکوردها
شواهد زنان، زایمان و کودکان
PubMed2028
Association between mid-to-late pregnancy gestational weight gain and adverse birth outcomes among women with gestational diabetes mellitus.
BACKGROUND AND OBJECTIVES: The gestational weight gain (GWG) range during mid-to-late pregnancy associated with the lowest combined risk of adverse birth outcomes in women with gestational diabetes mellitus (GDM) remains unclear. This study aims to examine the associations between GWG and adverse birth out-comes among women with GDM. METHODS AND STUDY DESIGN: This study included a cohort of 1,673 pregnant women with GDM. GWG was defined as weight gain from pre-pregnancy to a measurement between 24 and 32 gestational weeks, residualized for gestational age and standardized as z-scores. Multivariable logistic regression models were used to assess associations between GWG z-scores (per 1-SD increase and categories: <-1, -1 to 1 [reference], and ≥1) and small for gestational age (SGA), large for gestational age (LGA), and preterm birth. Restricted cubic splines were fitted to explore nonlinear associations. RESULTS: Each 1-SD higher in GWG z-score was associated with lower odds of SGA (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.43-0.71) and higher odds of LGA (1.48; 1.29-1.70). Compared with the reference group, women with GWG z-scores <-1 had higher odds of SGA and lower odds of LGA, whereas those with z-scores ≥1 showed the opposite pattern. No significant association was observed with preterm birth. Spline analyses indicated that a GWG z-score of approximately -0.07 (equal to 8.2 kg at 28 weeks) was associated with the lowest combined odds of SGA and LGA. CONCLUSIONS: Among women with GDM, both insufficient and excessive mid-to-late pregnancy GWG were associated with adverse size-for-gestational-age outcomes.
PubMed2027
AA and Male Fertility.
AA is known to play a significant role in male fertility. AA metabolites, prostaglandins (PGs), were first discovered in the seminal fluid. It was assumed at the time of its discovery that PGs were formed by the prostate and hence were named as prostaglandins. PGs are crucial for sperm function. Lower PGE2 in the semen was found in those who are infertile. NSAIDs (nonsteroidal anti-inflammatory drugs such as ibuprofen) are known to affect male fertility, sperm function, and semen parameters. These results suggest that potential use of AA and PGE2 to enhance male fertility needs to be studied.
PubMed2027
AA and Pregnancy.
AA is a crucial fatty acid in pregnancy, especially for the growth and development of the fetus and its central nervous system (CNS). As already discussed in the previous chapters, AA regulates inflammation, immune response, and cell signaling. AA has a modulatory action on gene expression, serves as a mechanotransducer, and regulates cell membrane fluidity. By regulating cell membrane fluidity, AA modulates the expression and binding of several receptors located on the cell membrane. Eicosanoids derived from AA have both beneficial and harmful effects on pregnancy. For instance, (i) AA metabolites such as 14,15-EET and 15-HETE are associated with gestational hypertension and preeclampsia, (ii) AA in association with DHA is crucial for the fetal nervous system and neurocognitive development of the newborn, and (iii) for the growth and development of the fetus, especially during the third trimester. LA and AA are involved in human fertility and in the pathobiology of gestational diabetes.
PubMed2027
AA in Hypertension and Preeclampsia.
Human essential hypertension is driven by a network of interacting nutritional, metabolic, inflammatory, and endothelial mechanisms in which AA and other PUFAs play a critical role. Beyond excess sodium intake, population data supports the role of inadequate calcium, potassium, and magnesium intake and low antioxidant vitamin status in shaping blood pressure regulation. These nutrients influence vascular smooth muscle tone and act as cofactors that support Δ6 and Δ5 desaturase activities, thereby governing tissue availability of AA, EPA, and DHA and downstream formation of vasodilator and antiplatelet mediators (e.g., PGE1, prostacyclin), as well as inflammation-resolving lipid mediators (lipoxins, resolvins, protectins, maresins, and nitrolipids).Endothelial dysfunction characterized by reduced endothelial nitric oxide (eNO) bioavailability and increased oxidative stress seems to play an important role in the pathobiology of HTN. High salt intake, asymmetric dimethylarginine (ADMA), and activation of NAD(P)H oxidase and angiotensin II signaling promote superoxide generation that quenches NO and shifts the vascular balance toward vasoconstriction. Clinical and experimental observations indicate that antihypertensive therapies can partly restore NO and antioxidant defenses, while dietary patterns rich in n-3 fatty acids (particularly DHA) and balanced n-6/n-3 intake may lower blood pressure by suppressing thromboxane formation and enhancing vasoprotective, pro-resolving pathways.Preeclampsia can be considered as a model of reversible hypertension linked to oxidative stress and angiogenic imbalance (sFlt1, soluble endoglin), highlighting mechanistic overlap with essential hypertension. Hypertension is a low-grade systemic inflammatory condition whose origins may be present in the perinatal period through long-term programming of PUFA metabolism and endothelial function.
PubMed2026
[THE CENTERS OF FEMALE HEALTH: INTERNATIONAL EXPERIENCE AND THE MOSCOW INNOVATIVE MODEL].
The global transformations in health care system, directed from reactive medicine to proactive and preventive model bring to the forefront issues of protection of female health. The health of woman is not only fundamental basis, but also key factor of social economic well-being of society, demographic stability and health of future generations. The traditional fragmented model of provision of obstetric gynecological care, focused mainly on treatment of already occurred pathologies and pregnancy management, demonstrates its inefficiency in the context of modern challenges: increase of chronic noncommunicable diseases, psycho-emotional loads and need of integration of reproductive health into general context of well-being of woman at all stages of her life. In the Russian Federation, the problem of modernization of obstetric gynecological service and, in particular, women consultations, is especially acute. Historically, The historically established system is often criticized for bureaucratization, insufficient focus on prevention and disparity between various levels of medical care. In this regard, emergence and implementation of new regional standards, in particular, metropolitan standard of obstetric gynecological care and Centers of Female Health is unique case requiring detailed scientific analysis and comparison with international advanced experience. The actuality of the study is conditioned by increasing need in developing new paradigm of medical care support of women, built on principles of complexity, continuity, personalization and orientation on prevention. The Centers of Female Health, integrating large spectrum of services, from screenings and diagnostics to psychological support and training programs, are considered by world community as gold standard of organization of such care.
PubMed2026
[THE CHARACTERISTICS OF COURSE OF PREGNANCY RESULTED FROM EXTRA-CORPOREAL IMPREGNATION AGAINST THE BACKGROUND OF GESTATIONAL DIABETES MELLITUS DEPENDING ON TERMS OF MANIFESTATION].
The pregnancy that occurred due to in vitro fertilization is characterized by higher risk of development of gestational diabetes mellitus. The purpose of the study was to investigate course and outcomes of pregnancy resulted from in vitro fertilization in women with gestational diabetes mellitus, depending on time of its manifestation. The analysis of course of pregnancy, childbirth and condition of newborns in 179 women with gestational diabetes mellitus under pregnancy resulted from in vitro fertilization was carried out. It is established that early manifestation of gestational diabetes mellitus is associated with older age of pregnant women, higher rate of birth of large fetus in anamnesis, higher body mass index, more frequent prescription of insulin therapy to treat gestational diabetes mellitus, higher rate of development of early threatened miscarriage, isthmic cervical insufficiency, anemia, chronic arterial hypertension, gestational arterial hypertension, moderate preeclampsia, severe preeclampsia, premature normally placed placenta detachment, fetal growth retardation, chronic intrauterine fetal hypoxia, diabetic fetopathy, prenatal rupture of amniotic fluid, premature birth, more frequent birth of large fetus, development of fetal renal pyelectasia. The female patients with late manifestation of gestational diabetes mellitus had higher level of fasting plasma glycemia, frequent development of placenta previa, polyhydramnios, pathological and insufficient gain of body mass during pregnancy, dis-coordination of labor and clinically narrow pelvis during labor, more frequent operative delivery and early delivery. The gestational diabetes mellitus, developed both in early and late periods, complicates the course and childbirth under pregnancy resulted from in vitro fertilization, adversely affects state of the newborn. The study in depth is needed to establish possible mechanisms of development of gestational diabetes mellitus in this cohort of women with implementation of screening examinations and determination of further tactics of management of pregnancy depending on time of its manifestation.
PubMed2026
[The Legal Regulation of Refusal of Medical Organizations and Physicians From Giving Service of Interruption of Pregnancy (Abortion) to Women in Countries of World Community].
The problem of availability of abortion services for women in countries of world community is not only not losing its importance, but is undergoing new stage of actualization, since it has no clear understanding and is often raised in the context of solving demographic problems of aging society. At the same time, analysis reveals vulnerability of position of those using religious context in womans self-determination regarding disposal of her own body and right to refuse compulsion to terminate her pregnancy by physiological childbirth without her psychological, social and economic readiness and public support. Referring to various testimonies and sources, we appeal to necessity of working out common criteria to ensure womens access to medical care related to procedure of abortion in order to reduce mortality from diseases associated with self-abortions menacing live and health of women. The issues considered in the study may affect various spheres of social, medical and legal field and have wide area of practical implementation. The purpose of the study is to identify causes and to establish consequences of womens limited access to abortion services, as well as legal and ethical aspects of overcoming these restrictions.
PubMed2026
ATI-2341 TFA promotes acquisition of epithelial-like immunophenotype in bone marrow mesenchymal stem cells and alleviates intrauterine adhesion in a rat model.
BACKGROUND: Intrauterine adhesion (IUA) is a common complication of endometrial injury. Bone marrow mesenchymal stem cells (BMSCs) have been implicated in endometrial repair, but strategies to enhance their therapeutic efficacy remain to be optimized. The C-X-C chemokine receptor type 4 (CXCR4)/C-X-C motif chemokine ligand 12 (CXCL12) axis plays a pivotal role in BMSC homing. OBJECTIVE: This study aimed to test the hypothesis that ATI-2341, a functionally selective allosteric regulator of CXCR4, enhances the therapeutic efficacy of BMSCs in a rat IUA model. METHODS: After establishing the endometrial injury model, rat BMSCs were extracted and treated with ATI-2341 TFA (100 ng/mL). IUA model rats were randomly divided into model control group, BMSCs group, BMSCs+ATI-2341 TFA group, BMSCs+PBS group and Positive control group (n=10 each). Endometrial thickness was assessed by hematoxylin and eosin (HE) staining; cell proliferation by the methyl thiazolyl tetrazolium (MTT) assay; matrix metalloproteinase-9 (MMP-9)/tissue inhibitor of metalloproteinase-1 (TIMP-1) protein expression by Western blot; and cytokeratin and vimentin expression by immunohistochemistry. RESULTS: ATI-2341 TFA-pre-treated BMSCs significantly increased endometrial thickness compared to untreated BMSCs (P < 0.05) or estrogen (P < 0.05). ATI-2341 TFA enhanced BMSC proliferation at 48 h (P < 0.05) and 72 h (P < 0.05). BMSCs exposed to ATI-2341 TFA or estrogen exhibited strong cytokeratin positivity and vimentin negativity. MMP-9 was downregulated (P < 0.05) and TIMP-1 upregulated (P < 0.05) in the ATI-2341 TFA group relative to controls. CONCLUSION: ATI-2341 TFA promotes acquisition of epithelial-like immunophenotype in BMSCs within the injured endometrial microenvironment and is associated with improved endometrial morphology in IUA rats. These findings provide preliminary evidence for the functional modulation of BMSCs by CXCR4-targeted therapy in endometrial repair.
PubMed2026
PBPK modeling of intravenous/oral acetaminophen in healthy and pregnant individuals.
BACKGROUND: Drug metabolism may be influenced by pregnancy. Use of acetaminophen (APAP) is prevalent among pregnant women, necessitating the development of effective methods for predicting its in-vivo disposition. OBJECTIVES: A whole physiologically based pharmacokinetic model was developed to predict the pharmacokinetic behavior of APAP following oral or intravenous administration in both healthy subjects and pregnant women across different trimesters (first, second, and third trimesters). METHODS: Phoenix WinNonlin 8.4 was used to establish the model, which was verified by literature data and the fold error method. Sensitivity analysis was used to identify the factors most sensitive to the model results. RESULTS: The model was established successfully. The clearance rate and half-life of intravenous APAP increased during pregnancy and the changes were more obvious with the increase of pregnancy trimesters. Theoretically, adjusting the oral and intravenous doses for pregnant women in the third trimester to 1.23 and 1.16 times those administered to healthy individuals may yield a comparable area under the curve in healthy subjects. According to the sensitivity analysis results, the influencing factors were ranked from largest to smallest as follows: activity of sulfatase > activity of glucuronidase > the constant of the gastrointestinal transport rate > activity of CYP450. CONCLUSION: Pregnancy affects the metabolism of APAP and more attention should be paid to pregnant women in clinical medication.
PubMed2026
Therapeutic drug monitoring-guided individualized caffeine dosing for apnea of prematurity: Clinical efficacy and association with early neurobehavioral outcomes in preterm infants.
BACKGROUND: Given the high incidence of apnea of prematurity (AOP) and the repeated hypoxia-induced nerve damage, treatment optimization from the dosing perspective is critical. Caffeine is the current first-line therapeutic drug for AOP. However, the conventional dose results in low blood concentration compliance, with significant variation among individuals. OBJECTIVES: To explore the clinical efficacy and safety of a therapeutic drug monitoring (TDM)-guided individualized caffeine dosage regimen and its association with early neurobehavioral development and weight gain in preterm infants (PTIs). METHODS: In this retrospective propensity score-matched cohort study, 130 PTIs with AOP were included after 1:1 matching, with 65 infants in the TDM-guided individualized dosing group and 65 in the conventional fixed-dose group. Inter-group comparative assessments were conducted from the perspectives of blood drug concentration compliance rates, apnea control, adverse reactions, neurobehavioral development scores, clinical outcomes and weight gain rates. RESULTS: Compared with the conventional fixed-dose group, the TDM-guided individualized dosing group had a significantly higher target attainment rate of blood caffeine concentration (92.31% vs 70.77%; OR=5.22, 95% CI 1.68-12.74, P=0.002), lower apnea episode frequency at 4 weeks (MD -1.40 times/day, 95% CI -2.13 to -0.67, P<0.001), lower overall incidence of adverse reactions (6.15% vs 20.00%; OR=0.26, 95% CI 0.09-0.87, P=0.035), higher NBNA score at 40 weeks of corrected gestational age (MD 1.74, 95% CI 1.23-2.25, P<0.001), shorter hospital stay (MD -4.11 days, 95% CI -6.51 to -1.71, P=0.001) and faster weight gain rate (MD 7.88 g/day, 95% CI 3.21-12.55, P=0.001). CONCLUSION: The TDM-guided individualized caffeine dosing regimen was associated with improved precision of AOP treatment, better short-term therapeutic efficacy and safety, and higher early neurobehavioral assessment scores and weight gain in preterm infants within 6 months of corrected gestational age. Multicenter studies with longer follow-up are needed to further verify its long-term clinical benefits.
PubMed2026
"How Long Is the Shadow of the Past?" the Relationship Between Adverse Childhood Experiences, Premenstrual Symptoms and Fear of Childbirth.
BACKGROUND: Adverse childhood experiences (ACEs) may have long-term effects on women's reproductive and psychological health, including premenstrual symptoms and fear of childbirth. PURPOSE: This study aimed to examine the relationships between ACEs, premenstrual syndrome (PMS), and fear of childbirth (FoC) among young women. METHODOLOGY: This cross-sectional and correlational study was conducted with 399 female university students in Türkiye between March and April 2022. Data were collected using the Adverse Childhood Experiences-Turkish Form (ACE-TF), Premenstrual Syndrome Scale (PMSS), and Women's Fear of Childbirth-Prior to Pregnancy Scale (WCF-PPS). Pearson correlation and linear regression analyses were performed. RESULTS: Of the participants, 58.6% reported at least one ACE and 71.7% had PMS symptoms. ACE scores were positively correlated with PMS (r = 0.476, p < 0.01) and FoC (r = 0.169, p < 0.01). PMS was also positively correlated with FoC (r = 0.455, p < 0.01). ACEs explained 22.5% of the variance in PMS scores (R2 = 0.225) and 2.6% of the variance in FoC scores (R2 = 0.026). CONCLUSIONS: Adverse childhood experiences were associated with greater premenstrual symptoms and fear of childbirth among young women. Incorporating trauma-informed assessment and individualized psychosocial support into reproductive health care may facilitate early identification of women at increased risk for reproductive and emotional distress.
PubMed2026
A National Pediatric Cohort Study on In-Hospital Cardiac Arrest in Sweden.
BACKGROUND: National data on pediatric in-hospital cardiac arrest (pIHCA) are limited, and cohorts from highly specialized pediatric centers may not reflect the broader hospital population. We aimed to describe pIHCA reported across Swedish hospitals, with particular focus on hospitals outside the two national centers for highly specialized pediatric cardiac care. METHODS: This retrospective observational registry study included patients aged 0-18 years with pIHCA reported to the Swedish Registry for Cardiopulmonary Resuscitation between January 1, 2005 and September 25, 2025. Cases from the two highly specialized centers were analyzed separately and as part of the complete national registry-reported cohort. The primary outcome was 30-day survival; secondary outcomes included return of spontaneous circulation (ROSC) and 1-year survival. RESULTS: Among 525 pIHCA events, 344 occurred outside the two highly specialized centers and 181 at these centers. In the broader Swedish hospital population, 31.7% of arrests occurred on hospital wards, 26.2% in emergency departments, and 22.7% in intensive care units. CPR was initiated immediately in 81.4% of events. Forty-nine percent survived to 30 days, and 44% to 1 year. At the two highly specialized centers, infants, congenital heart disease, and arrests in intensive care units were substantially more common, and 30-day survival was 70%. CONCLUSION: Patient characteristics, arrest location, and survival differed substantially between the broader Swedish hospital population and the two highly specialized centers. These findings highlight the heterogeneity of pIHCA across hospital settings and the importance of considering hospital type and case mix when interpreting pIHCA data. EDITORIAL COMMENT: Pediatric patient in-hospital cardiac arrest is uncommon, though they registered in a national database in Sweden. This analysis presents 20 years of experience and follow-up for these cases describing associated factors.
PubMed2026
Age-Specific Associations of Polygenic Risk Scores With Advanced Fibrosis and Histological Activity in Biopsy-Proven MASLD.
BACKGROUND AND AIMS: The genetic susceptibility to MASLD histological severity remains incompletely defined. We assessed the associations between recently developed genome-wide association studies-derived polygenic risk scores (PRSs) and advanced fibrosis in MASLD. We also evaluated PRSs' associations with histological activity and selected PRSs' predictive ability for advanced fibrosis. METHODS: We analysed 2149 adults and 900 children with biopsy-proven MASLD from the NASH Clinical Research Network studies. Genotyping was performed by the Regeneron Genetics Center using whole-exome sequencing with targeted genotyping. Associations between seven published PRSs (Chen, Emdin, Whitfield, Schwantes-An, Vujkovic, and Ghouse) and MASLD histological features were examined using linear and logistic regression models. Penalized regression models were used to select top PRSs associated with MASLD traits. RESULTS: The Schwantes-An PRS in adults (OR 1.29, 95% CI 1.17-1.42, p < 0.01) and the Chen PRS in children (OR 1.46, 95% CI 1.17-1.82, p < 0.01) were associated with higher risk of advanced fibrosis versus other PRSs. The Chen PRS in adults (OR 1.29, 95% CI 1.18-1.41, p < 0.01) and Schwantes-An PRS in children (OR 1.39, 95% CI 1.20-1.61, p < 0.05) were associated with higher risk with MASLD activity. Although highest PRSs quartiles were associated with advanced fibrosis risk versus bottom quartiles, neither PRS had good diagnostic discrimination for advanced fibrosis (AUROC < 60%). CONCLUSIONS: In this large biopsy-proven MASLD cohort, two distinct PRSs were associated with disease histological severity and activity in adults versus children. Findings suggest current PRSs may improve personalized risk stratification for advanced fibrosis but not its diagnosis.
PubMed2026
Antibiotic Use for Cystitis and Risk of Treatment Failure in Pregnancy Following Gastric Bypass: A Cohort Study.
Cystitis is common during pregnancy and requires effective antibiotic treatment to prevent complications. Gastric bypass surgery alters gastrointestinal anatomy and may impair oral drug absorption, raising concerns about antibiotic effectiveness. We therefore aimed to examine antibiotic use for cystitis and the risk of treatment failure in pregnant women with prior gastric bypass. In this nationwide Danish register-based study, we compared 1985 pregnancies among women with prior gastric bypass with 1 400 174 pregnancies among women without bariatric surgery. We assessed redeemed prescriptions for cystitis-related antibiotics and potential treatment failure defined as repeated antibiotic prescriptions within 14 days, hospital-recorded cystitis or severe urinary tract complications (pyelonephritis or urosepsis). Pregnant women with prior gastric bypass more frequently redeemed cystitis-related antibiotics than those without bariatric surgery (22.6% vs. 12.7%). Among antibiotic-exposed pregnancies, prior gastric bypass was associated with an increased risk of potential treatment failure, including repeated antibiotic prescriptions (adjusted odds ratio [aOR] 1.69, 95% confidence interval [CI] 1.22-2.30) and hospital-recorded cystitis (aOR 2.22, 95% CI 1.24-3.67), while severe complications were rare. These findings suggest that antibiotic treatment may be less effective or that the clinical course is more complicated in this group, highlighting a need for closer monitoring and tailored treatment strategies.
PubMed2026
Duo Nang Decoction enhances endometrial receptivity in PCOS rats by upregulating caveolin-1 expression.
BACKGROUND: Duo Nang Decoction (DND) is widely used for treating polycystic ovary syndrome (PCOS)-related infertility. However, the molecular mechanisms underlying its action remain unclear. In a previous study, downregulation of caveolin-1 (Cav-1) was shown to impair endometrial angiogenesis, a key determinant of endometrial receptivity. OBJECTIVES: This research study aimed to elucidate the influence and potential molecular mechanisms of DND on endometrial receptivity, specifically focusing on Cav-1 in PCOS rats. METHODS: Sprague Dawley (SD) rats (females, 3-week-old) were randomly categorized into the DND and aspirin cohorts. After successful PCOS modeling, the rats were orally administered DND or aspirin, respectively. Then, ovulation was induced and mating was performed. The rats were euthanized on the 2nd and 5th day of conception and the endometrium was extracted for histological evaluation via hematoxylin and eosin (HE) staining. Furthermore, immunohistochemistry (IHC) staining was carried out to assess Cav-1, vascular endothelial growth factor (VEGF) and β-catenin levels, as well as endometrial microvascular density (MVD). Moreover, reverse transcription polymerase chain reaction (RT-PCR) was used to measure the mRNA levels of VEGF and Cav-1 in the endometrium of both groups. RESULTS: The HE and IHC staining, as well as RT-PCR analysis of endometrial tissue slices, revealed that on the 2nd and 5th day of conception, both groups indicated significantly increased endometrial thickness, MVD and elevated levels of VEGF, Cav-1 and β-Catenin. However, the MVD in the DND group was substantially higher relative to the aspirin group. CONCLUSION: This study revealed that DND significantly enhanced endometrial angiogenesis and improved endometrial receptivity in PCOS rats. Mechanistically, the effects of DND on endometrial receptivity may be associated with the upregulation of Cav-1 and β-catenin. However, the specific mechanism of action warrants further research.
PubMed2026
Fathers' Newborn Care-Related Experiences: A Qualitative Study on Factors Affecting Their Participation in Neonatal Care and Support Needs.
AIM: This study aimed to investigate fathers' newborn care-related experiences, identify the factors affecting their participation in the care process and explore their support needs. METHODS: This qualitative study was conducted using a phenomenological design. Data were collected through in-depth face-to-face interviews conducted based on a semi-structured interview guide. The data were analysed using Colaizzi's phenomenological data analysis method. RESULTS: Fathers were willing to participate in newborn care and were particularly involved in practices such as feeding and basic hygiene care. Lack of experience, fear of harming the baby and lack of self-confidence regarding caregiving skills emerged as significant difficulties experienced by the fathers in newborn care. The fathers pointed out that their wives, healthcare professionals and family members were important sources of support, while demanding work schedules, limited paternity leave and traditional gender roles were among the leading barriers limiting their participation in caregiving. CONCLUSION: The fathers were willing to participate in newborn care, but their participation in the care process was limited owing to individual, social and structural barriers. It is believed that strengthening their caregiving skills and creating supportive environmental conditions will increase their participation in newborn care. IMPLICATIONS FOR PRACTICE: Healthcare professionals, particularly pediatric and neonatal nurses, should develop father-focused training programmes and provide guidance on care practices to encourage fathers to participate in newborn care actively. Developing policies that support paternity leave and family-centred care practices can also increase fathers' involvement in early infant care.
PubMed2026
Inadequate Neuraxial Anesthesia in Patients Undergoing Emergency Cesarean Delivery: A Qualitative and Quantitative Scoping Review.
BACKGROUND: Neuraxial anesthesia is the preferred anesthetic technique for cesarean delivery, yet a systematic review found that 14% of blocks for elective cesarean delivery were inadequate. This scoping review aimed to explore patients' and anesthesiologists' experiences of inadequate neuraxial anesthesia during emergency cesarean delivery. Secondary objectives were to examine its definitions, management strategies, and reported prevalence. METHODS: A systematic literature search was conducted based on predefined inclusion criteria according to the PCC framework (Population, Concept, Context). Studies published since 1995 that reported clinical data were eligible. Three authors independently screened titles, abstracts, and full texts. Study quality was assessed using the Mixed Methods Appraisal Tool. RESULTS: The literature search yielded 6375 titles, of which 63 were included in the review. Data on patients' and anesthesiologists' experiences with inadequate neuraxial anesthesia during emergency cesarean delivery is very limited. Clinicians may experience difficulties identifying patients experiencing intraoperative pain. No common definition of "inadequate neuraxial block" was found. Intravenous opioids followed by S-Ketamine were the most common pharmacological strategies used for supplementation. Due to the varying definition of "inadequate block" no incidence could be calculated. CONCLUSION: Data on both patients' and anesthesiologists' experiences with inadequate neuraxial anesthesia during emergency cesarean delivery are sparse. Inadequate neuraxial anesthesia is inconsistently assessed, and with no consensus on its definition or management. A wide range of pharmacological strategies is used to avoid conversion to general anesthesia, but their effectiveness remains unclear. The reported incidence of inadequate neuraxial block ranges from 0% to 27%. EDITORIAL COMMENT: This scoping review presents an updated systematic review on how to better understand this kind of event, so that it could be better studied.
PubMed2026
Longitudinal links between prenatal maternal depression and anxiety symptoms and infant temperament: The roles of postnatal symptoms and perceived partner support.
The perinatal period is marked by heightened vulnerability to maternal depression and anxiety symptoms, which have been associated with early child socio-emotional development, including difficult temperament. This longitudinal study investigated whether prenatal maternal depression and anxiety symptoms predicted infant difficult temperament at 12 months through parallel mediation by postnatal maternal symptoms and perceived partner support. Given emerging evidence on sex differences in the associations between prenatal maternal distress and early socio-emotional development, exploratory multi-group analyses by child sex were also conducted. Pregnant individuals were recruited (October 2020-September 2022) for the Resilience and Perinatal Stress during the Pandemic (RESPPA) study in Quebec, Canada. Measures included the EPDS, GAD-7, ICQ, and perceived partner support assessed via self-reported online questionnaires. Path analyses (N = 1422) were conducted using data from the third pregnancy trimester (T1), three months postpartum (T2), and 12 months postpartum (T3). Separate models were estimated for depression and anxiety symptoms. Greater prenatal depression symptoms predicted higher infant difficult temperament scores, with postnatal depression symptoms and perceived partner support fully mediating this association. Similar findings emerged for anxiety. No significant sex differences were observed. Findings highlight postnatal maternal depression and anxiety symptoms and perceived partner support as potential screening and intervention targets to promote infant development.
PubMed2026
Maternal Exposure to Witnessed Social Defeat Stress Induces Sex-Specific Disruptions in Juvenile Social Play Behavior in Rats.
Stressing rodent dams during lactation can impair offspring neurodevelopment, altering behavioral and physiological outcomes. Witnessed social defeat stress (WSDS) is a paradigm in which a juvenile or adult rodent observes aggressive encounters, affecting stress physiology and behavior. We developed a novel early-life stress model by exposing lactating rat dams to WSDS and assessed its impact on juvenile social behavior and stress-related physiology. At postnatal day 24, same-sex, age-matched pairs of offspring were tested for social play by scoring pouncing (play initiation), pinning, chasing, and evading. Locomotor activity was assessed in the open field on the same day. After behavioral testing, adrenal cortex weight was measured as an indirect marker of stress-related physiology. Maternal WSDS exposure was associated with a significant sex × WSDS interaction in pouncing behavior, with reduced pouncing in juvenile males, whereas no comparable effect was observed in females. WSDS exposure also increased adrenal cortex weight overall, although the sex × WSDS interaction for this measure was not significant. The reduction in pouncing was characterized by substantial within-group variability, and randomization-based sensitivity analysis indicated that the statistical significance of the sex × WSDS interaction was sensitive to focal-animal assignment. These findings suggest that maternal WSDS exposure may produce a specific and variable alteration in social play initiation, together with changes in stress-related physiology, during early juvenile development. This model may provide a useful framework for investigating how maternal psychosocial stress influences offspring behavioral and physiological development.
PubMed2026
MicroRNA-135 alleviates cisplatin resistance in cervical cancer by inhibiting CD44v6.
BACKGROUND: Cervical cancer (CC) remains a leading cause of cancer-related mortality worldwide and cisplatin resistance poses a major challenge to effective treatment. MicroRNA-135 (miR-135) has been implicated in tumor progression and drug resistance, but its role in cisplatin-resistant CC remains unclear. OBJECTIVES: To investigate whether miR-135 affects cisplatin resistance in CC cells by targeting CD44v6. METHODS: Bioinformatic analysis (TargetScan) was performed to predict the miR-135 binding site in CD44v6, followed by a dual-luciferase reporter assay. RT-qPCR and Western blot were used to measure miR-135 and CD44v6 expression in cisplatin-resistant HeLa/DDP cells, HeLa cells and normal Ect1/E6E7 cells. HeLa/DDP cells were transfected with miR-135 mimic or NC mimic and cell proliferation (CCK-8, colony formation), apoptosis (flow cytometry) and CD44v6 expression were assessed. RESULTS: miR-135 directly bound to the CD44v6 3'-UTR, reducing luciferase activity by 58% (*p* < 0.001). miR-135 expression was decreased by 68% in HeLa/DDP cells compared to Ect1/E6E7 cells, while CD44v6 expression was increased 3.5-fold. miR-135 mimic transfection reduced CD44v6 protein expression by 62%, decreased cell viability by 57.3%, increased the apoptosis rate from 12.4% to 35.8% (absolute increase of 23.4%) and lowered the cisplatin IC50 from 22.36 to 8.47 μmol/L (2.64-fold reversal, *p* < 0.001). CONCLUSIONS: miR-135 overexpression was associated with reduced CD44v6 expression, decreased proliferation, increased apoptosis and enhanced sensitivity to cisplatin in HeLa/DDP cells. These findings demonstrate an inverse association between miR-135 and CD44v6 in cisplatin-resistant CC cells; however, causal mechanistic evidence (e.g., via CD44v6-specific knockdown or rescue experiments) is not provided. Further studies are required to establish whether CD44v6 directly mediates the chemosensitizing effects of miR-135.
PubMed2026
Prehospital Births in the Region of Southern Denmark-A Cohort From 2016 to 2024.
BACKGROUND: Unplanned births outside hospitals involve higher risks of complications for mothers and newborns and require special obstetric or pediatric skills. However, ambulance calls for childbirth are rare, making it difficult for ambulance staff to maintain their skills. In Europe, unplanned out-of-hospital deliveries constitute 0.10% to 0.61% of all births. The exact number of prehospital births in the Region of Southern Denmark remains unknown. The study aimed to determine the extent of unplanned prehospital births attended by the ambulance service outside hospitals in the Region of Southern Denmark from January 2016 through June 2024. We further aimed to identify where the unplanned pre-hospital births took place and to report any birth-related complications in the mothers or newborns encountered by ambulance staff. METHODS: The study was a cross-sectional study utilizing the pre-hospital electronic Patient Medical Record system over 8 years in a mixed urban-rural area with a population of 1.2 million people. All prehospital medical records for ambulance missions dispatched for childbirths were manually examined. The study period spanned from January 2016 through June 2024. RESULTS: Out of 1,137,222 ambulance dispatches, 3543 cases (0.31%) involved a dispatch code related to childbirth. Many labor incidents were considered uneventful by the prehospital personnel. Of all ambulance runs related to childbirth, we identified 310 births in the Region of Southern Denmark in which ambulance staff assisted with complicated out-of-hospital deliveries. An additional 10 labor cases were regarded as sufficiently complex that obstetric manoeuvres aimed at delaying the delivery of the baby were performed prehospitally, while the mother was rushed to hospital for delivery. CONCLUSION: Births outside the hospital while the mother is in the care of the EMS were rare, occurring in 0.03% of all ambulance missions. Most of the births took place without complications for both mother and neonate. In four cases, however, the neonate was in cardiac arrest and required resuscitation. Given the limited exposure to prehospital births, we suggest incorporating training in handling these rare events into routine training for prehospital caregivers. EDITORIAL COMMENT: This cohort study presents obstetrical cases that have been managed first in the prehospital setting by ambulance personnel. Obstetrical outcomes related to this are presented, and there are considerations for what can be desirable as preparation and competencies for ambulance responses for these types of cases.
PubMed2026
Temperature Dysregulation Following Intrathecal Morphine for Cesarean Delivery Patients-A Scoping Review.
BACKGROUND: Intrathecal morphine is widely used for postoperative analgesia following cesarean delivery. However, intrathecal morphine's potential association with hypothermia remains uncertain, although hypothermia may adversely affect maternal recovery and comfort. This scoping review aims to map the available evidence regarding temperature dysregulation associated with intrathecal morphine in patients undergoing cesarean delivery. METHODS: We conducted a scoping review according to the PRISMA-ScR guideline. A systematic literature search was performed in Medline, Embase, The Cochrane Library, and Cinahl. Studies reporting temperature outcomes in patients receiving intrathecal morphine during cesarean delivery were eligible. The primary outcome was the incidence of hypothermia or hyperthermia. Secondary outcomes included changes in core temperature, dose-response relation, duration, severity of temperature dysregulation, and impact on recovery. RESULTS: A total of 35 studies published between 1991 and 2025 were included. Four studies evaluated intrathecal morphine as intervention, whereas it was administered as standard care provided for all trial patients in the remaining studies. A total of 20 studies reported the incidence of hypothermia, corresponding to a pooled incidence of 21% among 773 patients. No studies reported an increase in temperature. A total of 12 case reports described severe hypothermia attributed to intrathecal morphine. However, our explorative analysis did not show an association between intrathecal morphine and hypothermia, and no dose response was identified. Clinical outcomes were infrequently reported, though several hypothermic patients were described as asymptomatic, suggesting that hypothermia may be clinically under-recognized. CONCLUSION: Current evidence does not demonstrate a consistent association between intrathecal morphine and hypothermia following cesarean delivery. However, interpretation is limited by substantial heterogeneity across studies. This scoping review highlights an important evidence gap in the literature and supports the need for well-designed studies to clarify whether intrathecal morphine contributes to clinically relevant hypothermia. EDITORIAL COMMENT: This review presents an overview of the evidence concerning intrathecal morphine treatment and post-caesarean temperature dysregulation. The evidence is incomplete, and this scoping review highlights areas where higher quality evidence is needed.
PubMed2026
The Application of Nurse-Led Bedside Critical Care Ultrasound in Paediatric and Neonatal Nursing Practice: A Scoping Review.
BACKGROUND: Point-of-care ultrasound (POCUS) is increasingly used in paediatric and neonatal critical care, but evidence on nurse-led bedside POCUS remains limited and fragmented. AIMS: This scoping review aimed to map the evidence on nurse-led bedside POCUS in paediatric and neonatal critical care nursing practice, examine implementation factors and identify evidence gaps relevant to nursing research, education and clinical practice. METHODS: Following JBI methodology and PRISMA-ScR guidance, we searched PubMed, Embase, CINAHL, Web of Science, Cochrane Library and CNKI from inception to October 2025. Eligibility followed the PCC framework. Two reviewers independently screened records and extracted data using a standardized form. Study characteristics were synthesized descriptively, and implementation factors were deductively analysed using the COM-B framework. RESULTS: Thirty-four studies were included, mainly from the United States and China. Nurse-led POCUS applications included vascular access, respiratory assessment, catheter localization, cardiac or hemodynamic evaluation, bladder assessment and education or competency development. Outcomes included clinical (procedural success and diagnostic accuracy), process (timeliness and workflow efficiency) and nurse-related (competency, confidence and role development). Safety-related outcomes were the least reported. Implementation was influenced by training, equipment, protected time, institutional support, collaboration and patient safety concerns. The automatic motivation domain, referring to unconscious drivers such as habits and emotional responses, was not addressed by any study. CONCLUSIONS: Nurse-led POCUS is an emerging but unevenly developed component of paediatric and neonatal critical care. Brief training may support initial competency, but sustained implementation is constrained by underdeveloped quality assurance, unclear career pathways and limited attention to motivational processes. RELEVANCE TO CLINICAL PRACTICE: Future nursing research and clinical programmes may look beyond short-term training outcomes to consider competency standards, longitudinal supervision, quality assurance, educational approaches combining foundational POCUS training with structured workplace supervision and sustainable integration into routine care delivery.
PubMed2026
The Politics of Reproductive Signification: Navigating Legal Definitions of Parenthood in the Context of UK Informal Donor Conception.
Informal donor conception (IDC) has an ambiguous status under UK law. Whilst not illegal, it is discouraged by regulators and only partially recognised in attributions of legal parenthood. In this paper, we analyse IDC as a lens to explore the politics of reproductive signification. We use this term to refer to the power dynamics at play in deciding the meaning of reproductive processes in people's everyday lives. Drawing on interviews with 19 donors and 30 (intended) parents via IDC, we explore how they manage the relational significance of conception, gestation and care in the context of a legal regime which is often at odds with their intentions. Building on theories of legal consciousness and stratified reproduction, we demonstrate how the politics of reproductive signification encompass not only cis/heteronormative legislation but also the ways in which inequalities, relating to economic resources, racialised and classed parenting ideals and relationship status, shape possibilities to work with the law and resist its relational authority via practices of de-animation or embrace legal ambiguity. Our analysis has implications for understanding how people negotiate the meaning of reproduction, particularly in the context of legal marginalisation.
PubMed2026
Acceptability and preference of self-collected vaginal samples for human papillomavirus DNA testing compared with physician-collected Pap smear.
BACKGROUND: Self-collected vaginal sampling for human papillomavirus (HPV) DNA testing provides a promising alternative to physician-collected Pap smears, especially in low-resource settings. However, data on its acceptability and preferences among Filipino women remain limited. This study aimed to assess women's perceptions, experiences, willingness and preferences regarding self-collected vaginal sampling for HPV DNA testing compared with Pap smears. METHODS: A cross-sectional study was conducted among 592 women. Participants underwent both physician-collected Pap smears and self-collected vaginal sampling for HPV DNA testing. Perceptions were measured using five-point Likert scale questionnaires before and after self-collection. Descriptive statistics were used, and paired and independent Wilcoxon tests were used to compare Likert responses. Willingness to undergo screening was analyzed with Cochran's Q and McNemar tests. Participants' reasons for their preferred screening method were categorized thematically and displayed in stacked bar charts. RESULTS: Self-collection was generally viewed as painless, not uncomfortable, non-embarrassing, and easy and convenient. Acceptability significantly increased after participants performed self-collection (P < 0.001 for pain and discomfort). Compared with Pap smears, self-collection was seen as less embarrassing (P < 0.001), but rated as less easy (P = 0.01) and less convenient (P = 0.004). Most participants preferred physician-administered screening (84.8%) due to trust in medical expertise, and confidence in the procedure's accuracy, safety and cleanliness. CONCLUSIONS: Self-collected vaginal sampling was highly acceptable, yet physician-collected screening remained the preferred method. Improving education, demonstrations, and support for self-collection may enhance the uptake of HPV DNA testing and broaden access to cervical cancer screening in the Philippines.
PubMed2026
Clinical outcomes and management of syphilis during pregnancy amidst the Northern Territory syphilis outbreak: a 10-year retrospective cohort study.
BACKGROUND: This retrospective study describes the clinical outcomes and management of people diagnosed with syphilis during pregnancy and their newborns at risk of congenital syphilis in the Northern Territory (NT), Australia between 2013 and 2023. METHODS: Demographic, clinical, and contact tracing information on all pregnancies with syphilis diagnosed prior to or during pregnancy, and clinical information of neonates, were sourced from spreadsheets and the NT Syphilis Register Information System. RESULTS: A total of 380 pregnancies were monitored, of which 186 pregnancies were identified as at risk of mother-to-child transmission of syphilis. Reinfection accounted for 13.8% of the 181 new syphilis infections. Of the 188 neonates, there were 11 cases of congenital syphilis, including 1 case of stillbirth. All congenital syphilis cases occurred when maternal syphilis was diagnosed in the third trimester or at the time of childbirth. While maternal treatment was completed in all pregnancies, 22 (11.8%) received treatment less than 30 days prior to childbirth or were untreated at the time of childbirth. Initial treatment was inadequate in 10 pregnancies (5.4%). A lack of four-fold reduction in rapid plasma reagin (RPR) titres by the time of childbirth due to delayed diagnosis and treatment was significantly associated with neonatal congenital syphilis (P < 0.001), with a median RPR of 1:8. Among identified contact/s, 54 (43.2%) tested positive for syphilis. CONCLUSION: Early detection, treatment, and follow-up of maternal syphilis before and during pregnancy are key measures to prevent congenital syphilis. Universal syphilis screening with repeat testing should be incorporated into antenatal care to minimise stigma.
PubMed2026
Psychometric evaluation of the Chinese version of the desire to avoid pregnancy scale among emerging adults in China.
BACKGROUND: Measures of fertility preference or intention, particularly those focused on fertility prevention, are increasingly needed in reproductive health, especially in countries such as China, which face challenges, such as declining fertility rates, an aging population and unintended pregnancies among young adults. This was the first study to take initial steps in addressing these issues by translating, validating and examining the latent structure of the unidimensional Desire to Avoid Pregnancy (DAP) scale, which has been shown to predict contraceptive use and pregnancy. METHODS: We conducted an online survey among emerging adults in China using convenience sampling. A total of 893 participants completed the survey. Psychometric properties were examined by assessing internal consistency, structural validity (via exploratory factor analysis and confirmatory factor analysis) and convergent validity. RESULTS: A three-factor structure of the 13-item Chinese version of the DAP scale was identified (AIC = 12,569.76), outperforming the one-factor model (AIC = 13824.834), with satisfactory reliability (AVE: F1 = 0.74, F2 = 0.74, F3 = 0.72; ρc: F1 = 0.90, F2 = 0.86, F3 = 0.76), accounting for 72.77% of the total observed variance. Convergent validity was supported by the expected positive correlations of the DAP scale scores with general anxiety and childbearing-specific worries, and a negative correlation with attitudes toward the importance of fertility for the future. CONCLUSION: The three-factor DAP scale was shown to be a valid, reliable tool for researching reproductive health literacy and fertility intention among Chinese emerging adults. Its three subscale scores and patterns can capture ambivalent desire, facilitating more precise screening and assessment in reproductive health contexts.
PubMed2026
Sexual function outcomes after a multicomponent protocol incorporating 1-minute daily vaginal dilation for genito-pelvic pain/penetration disorder: a retrospective multicentre study.
BACKGROUND: Vaginal dilators are used to manage genito-pelvic pain/penetration disorder, but longer daily sessions may increase treatment burden. This study evaluated achievement of intercourse and sexual-function outcomes following a multicomponent protocol incorporating 1-min daily vaginal dilation (AM-1 protocol). METHODS: This retrospective multicentre observational study screened 156 consecutive women with genito-pelvic pain/penetration disorder treated at YPK Mandiri Hospital and Bunda General Hospital, Jakarta, Indonesia, between January 2021 and October 2024. Of these, 123 initiated the AM-1 protocol as sole treatment, and 113 had complete paired pre-treatment and post-treatment Female Sexual Function Index-6 (FSFI-6) data for analysis. The AM-1 protocol combined psychoeducation, pelvic floor relaxation, cognitive reframing and progressive 1-min daily dilation. Outcomes were patient-reported successful unassisted penile-vaginal intercourse and paired FSFI-6 scores assessed at least 4 weeks after successful intercourse. RESULTS: Successful intercourse was documented in 113 of 123 women who initiated the AM-1 protocol as sole treatment (91.9%; 95% CI 85.6-96.0%); 10 women had no documented follow up and their outcomes were unknown. Among 113 complete cases, median total FSFI-6 score increased from 14 (interquartile range 10-16) before treatment to 22 (IQR 20-26) after treatment, with a median within-participant increase of 10 points (IQR 8-12; P < 0.001). Probable female sexual dysfunction decreased from 100% to 23.9% (P < 0.001). CONCLUSIONS: In this study, the AM-1 protocol was associated with documented successful intercourse and improved FSFI-6 scores. Comparative studies are needed to determine whether the brief dilation duration improves adherence or outcomes.
PubMed2026
Trends of sexually transmitted infections among pregnant women in Melbourne, Australia, 2012-2025: a rise in burden of syphilis.
BACKGROUND: Sexually transmitted infections in pregnancy threaten both mother and baby, so early detection matters. This study aimed to describe the epidemiology and temporal trends of sexually transmitted infections (STIs) among pregnant women attending a large public sexual health clinic in Melbourne, Australia, from 2012 to 2025. METHODS: We retrospectively analysed electronic medical records from the Melbourne Sexual Health Centre, a large public sexual health service. Demographic, clinical, and laboratory data were extracted for pregnant women who attended in 2012-2025, including those referred by primary care providers. STI positivity were calculated with 95% confidence intervals (CI), and temporal trends were assessed using trend tests. RESULTS: Of 659 pregnant women, 111 (16.8%, 95% CI: 14.2-19.9%) had one or more STIs. Positivity was 12.2% (46/377) for syphilis, 10.9% (57/523) for chlamydia, 2.1% (9/385) for gonorrhoea, 0.6% (2/335) for HIV, and 2.3% (5/218) for trichomoniasis. Of syphilis cases, 73.9% were diagnosed in the first trimester. Syphilis positivity increased over the study period (Ptrend = 0.022), peaking in 2022-2023 (35.0%, 7/20), while other STIs remained stable. CONCLUSIONS: STIs were frequently detected among pregnant clinic attendees, with syphilis and chlamydia the most prevalent. The rising burden of syphilis highlights the need for strengthened antenatal testing and timely public health responses.
PubMed2026
Effects of naringenin on superovulation in mice: evaluation of zygote and blastocyst development, histopathology, and molecular docking insights.
CONTEXT: Naringenin is a citrus-derived flavanone with documented antioxidant, anti-inflammatory, and steroidogenic modulatory properties; yet, its effects under gonadotropin-stimulated superovulation have not been investigated. AIMS: This study evaluated the impact of naringenin co-administration during a pregnant mare serum gonadotropin (PMSG)/human chorionic gonadotropin (hCG) superovulation protocol on zygote yield, preimplantation embryo development, and ovarian and endometrial morphology in CD-1 mice. METHODS: Twenty-four females (8-10 weeks) received PMSG with either naringenin (20 mg/kg intraperitoneally; n = 12) or dimethyl sulfoxide vehicle (n = 12), followed by hCG 48 h later and mating with fertile males. Pronuclear-stage embryos were collected from oviducts 14-16 h post-mating and cultured in vitro for 96 h; cleavage and blastocyst formation were assessed at 24 h and 96 h respectively. Ovarian and uterine tissues were evaluated histopathologically. KEY RESULTS: Naringenin treatment significantly increased total zygote yield. Although cleavage rate was lower in the naringenin group (45% vs 53%), blastocyst formation among cleaved embryos was markedly higher (47% vs 25%). Treated animals exhibited significantly greater corpora lutea count, corpora lutea:cell ratio, ovarian diameter, and endometrial thickness. In silico molecular docking predicted favourable binding affinities of naringenin towards the progesterone receptor and follicle-stimulating hormone receptor, generating a computational hypothesis consistent with these in vivo findings. CONCLUSIONS: Naringenin enhances blastocyst developmental competence and post-ovulatory ovarian parameters under superovulation conditions. IMPLICATIONS: These findings support the potential of naringenin as an adjunct to gonadotropin-based reproductive biotechnology protocols.