Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives.

چکیده اصلی

Hyaluronic acid (HA), a cell behavior modulator with anti-aging, anti-inflammatory, and immunomodulatory properties, is a member of the glycosaminoglycan family. In orthopedics, HA has been utilized for its chondroprotective, anti-inflammatory, immunomodulatory, and cushioning effects, owing to its extreme lubricity and hydrophilicity. HA has been investigated for various diagnostic and therapeutic applications in spinal diseases. This narrative review aimed to clarify that HA may serve as a biomarker in spinal diseases and as a therapeutic agent in several applications, such as tissue engineering for intervertebral disc degeneration, management of spinal pain, prevention of postoperative epidural fibrosis, and minimally invasive treatment of vertebral compression fractures. Although the efficacy of HA as a viable alternative or adjunct to existing therapies for various spinal conditions has been investigated, further experimental and clinical studies are required to explore regulatory considerations, refine clinical applications, and develop potential interdisciplinary management strategies before general recommendations can be established.

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