Dose-Response Relationship Between Physical Activity and Intrinsic Capacity Decline Among Hospitalised Older Patients.

چکیده اصلی

OBJECTIVE: Intrinsic capacity (IC) serves as the foundation for functional performance in older adults, and its decline exerts a significant negative impact on their overall health status. However, the dose-response relationship between physical activity (PA) and IC decline is unclear. The objective of this study was to examine the dose-response relationship between PA and IC decline in hospitalised older adults. METHODS: This cross-sectional study was conducted from August 2024 to July 2025, with hospitalised older patients recruited from three tertiary hospitals in Gansu Province, China. Data were collected using a general information questionnaire, the IC Assessment Scale and the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Binary logistic regression and restricted cubic spline (RCS) models were used to explore the association between PA and IC decline, adjusting for potential confounders. RESULTS: The final analyses included a total of 534 hospitalised older patients. Using the low PA group as the reference, the moderate PA group was associated with a 66% lower likelihood of IC decline (OR = 0.34, 95% CI: 0.23-0.50), and the high PA group was associated with a 74% lower likelihood (OR = 0.26, 95% CI: 0.14-0.49). In the RCS analysis, a J-shaped nonlinear association was observed between PA levels and IC decline. Subgroup analyses by sex indicated that sex may serve as a potential moderator in the association between PA and IC decline. CONCLUSIONS: This study revealed a J-shaped nonlinear association between PA and the likelihood of IC decline, with moderately higher PA levels associated with a lower likelihood of IC decline.

ترجمه فارسی چکیده

هدف این مطالعه بررسی رابطه دوز-پاسخ بین فعالیت بدنی و افت ظرفیت درونی در بیماران مسن بستری بود. این مطالعه مقطعی از اوت ۲۰۲۴ تا ژوئیه ۲۰۲۵ در سه بیمارستان تخصصی استان گانسو چین انجام شد. داده‌ها با پرسشنامه اطلاعات عمومی، مقیاس ارزیابی ظرفیت درونی و پرسشنامه بین‌المللی فعالیت بدنی-فرم کوتاه جمع‌آوری شد. از رگرسیون لجستیک دودویی و مدل‌های منحنی سینوسی محدود برای بررسی رابطه استفاده شد. در نهایت ۵۳۴ بیمار مسن وارد تحلیل شدند. گروه فعالیت بدنی متوسط با ۶۶٪ کاهش احتمال افت ظرفیت درونی (OR = ۰.۳۴) و گروه فعالیت بدنی بالا با ۷۴٪ کاهش احتمال (OR = ۰.۲۶) مرتبط بود. تحلیل منحنی سینوسی محدود نشان‌دهنده یک رابطه غیرخطی شکل J بین سطوح فعالیت بدنی و افت ظرفیت درونی بود. تحلیل‌های زیرگروهی نشان داد که جنسیت ممکن است عامل تعدیل‌کننده‌ای باشد.

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