PubMed دسترسی آزاد

A Review: Bovine Coronavirus Evolution, Molecular Epidemiology, and Genetic Variation.

Dong Wang, Wenzheng Zhang, Zheng Nie, Xutian Wang, Jinhui Liu, Yannan Zhang, Yabin Lu, Zhanhai Mai, Xiaodong He, Jianlong Li, Chao Gong, Qingyong Guo• 2026• Viruses
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پخش حرفه‌ای فارسی و انگلیسی

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خواندن هوشمند فارسی و انگلیسی در حال آماده‌سازی صداهای مرورگر…
تنظیم صدای طبیعی و سرعت

صداهایی که در نامشان «Natural»، «Neural» یا «Online» دیده می‌شود معمولاً طبیعی‌ترند. انتخاب صدا به صداهای نصب‌شده در ویندوز و مرورگر شما بستگی دارد.

چکیده اصلی

Bovine coronavirus (BCoV) is a key pathogen causing calf diarrhea and bovine respiratory diseases, bringing sustained economic losses to the cattle industry. As an RNA virus, BCoV possesses high mutation and recombination capacities, leading to prominent genomic genetic diversity. The genome contains hypervariable and conserved regions, with the S (especially S1), HE and Open Reading Frame (ORF4) genes serving as major variation hotspots linked to viral antigenicity, tissue tropism shift and immune evasion. Host immune pressure drives strong positive selection on S protein antigenic variation. This review discusses existing research limitations and proposes future directions including genomic surveillance, reverse genetics verification and broad-spectrum vaccine development to support BCoV prevention and control.

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کلیدواژه‌ها

bovine coronavirusgenetic variationhost geneticsmolecular epidemiologyphylogeneticsspike protein
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