PubMed چکیده/رکورد

Real-life durability and virological outcomes of doravirine in people with multidrug-resistant HIV.

Tommaso Clemente, Nicolò Capra, Vincenzo Malagnino, Riccardo Lolatto, Sergio Lo Caputo, Laura Comi, Andrea Giacomelli, Giovanni Cenderello, Manuela Colafigli, Stefano Rusconi, Maurizio Zazzi, Antonella Castagna, PRESTIGIO Study Group• 2026• AIDS (London, England)
استودیوی صوتی مقاله

پخش حرفه‌ای فارسی و انگلیسی

در حال بررسی نسخه‌های صوتی ذخیره‌شده…

صوت تولیدشده با هوش مصنوعی است. برای کاربرد علمی یا درمانی، متن و منبع اصلی را بررسی کنید.
خواندن هوشمند فارسی و انگلیسی در حال آماده‌سازی صداهای مرورگر…
تنظیم صدای طبیعی و سرعت

صداهایی که در نامشان «Natural»، «Neural» یا «Online» دیده می‌شود معمولاً طبیعی‌ترند. انتخاب صدا به صداهای نصب‌شده در ویندوز و مرورگر شما بستگی دارد.

چکیده اصلی

Outcomes of doravirine in heavily treatment-experienced people with HIV (PWH) remain poorly defined, despite in vitro activity against multiple resistance patterns. In this multicenter cohort of 4-class drug-resistant PWH, we evaluated durability and outcomes of doravirine-containing regimens. Among 52 individuals, doravirine was maintained in 63.5% over a median of 2.4 years. Viral load <50 copies/ml was achieved in 58.6% of viremic initiators, but maintained in 82.6% of nonviremics. Findings support genotype-informed doravirine use within complex regimens, particularly for switching in nonviremics.

متن کامل اصلی

متن در JumpToDate ذخیره نشده است.

برای بررسی دسترسی کتابخانه‌ای یا خرید، رکورد اصلی را باز کنید.

رفتن به منبع اصلی
در همین زیرشاخه

مقاله‌های مرتبط

PubMed2027

Assays of Antifungal Activity of an Antimicrobial Peptide Against Botrytis cinerea.

Antimicrobial peptides (AMPs) represent the first line of host immune defense against a broad spectrum of microorganisms. Whether naturally occurring or synthetically designed, these small peptides can potently inhibit microbial growth and remain stable under diverse conditions. Most AMPs act by directly disrupting fungal or bacterial membranes. In this study, we identified a glycine-rich peptide with strong antifungal activity against…

PubMed2027

Assessing Sensitivity to Antifungal Plant Compounds or Agrochemicals.

Botrytis cinerea, a major fungal pathogen of crops, has been extensively studied for its resistance to antifungal plant metabolites and agrochemicals. Evaluating the sensitivity of B. cinerea to these compounds is crucial for understanding its pathogenicity and for developing effective plant protection strategies. This study describes two methods for antifungal sensitivity assessment: the spot assay, which visualizes fungal growth on a…

PubMed2027

Assessing the Vector Competence for Chikungunya Virus in Mosquitoes.

Chikungunya virus (CHIKV) is a human pathogenic, mosquito-borne virus (arbovirus), which is causing epidemic outbreaks among human populations in Africa, Asia, Europe, and South- and Central America including the Caribbean. The development of novel approaches to prevent mosquito transmission of the virus in the field requires a detailed study of CHIKV interactions with its mosquito vectors in the laboratory. In this chapter, we describ…

PubMed2027

Automated Counting of Chikungunya Virus-Formed Plaques.

The cytopathic effect (CPE) is a key to understanding the pathogenicity of the chikungunya virus (CHIKV) and is useful for evaluating viral infectivity in vitro. The plaque assay, based on the CPE induced by viral infection, provides an infectious virus titer for test samples. Additionally, the assay is simple, quantitative, and cost-effective. Thus, the plaque assay remains the gold standard for determining the infectivity of CHIKV. H…