PubMed چکیده/رکورد

[Antibody therapy in Alzheimer's disease].

Marlena Schnieder• 2026• Zeitschrift fur Gerontologie und Geriatrie
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چکیده اصلی

Alzheimer's disease, the leading cause of dementia, is defined by extracellular amyloid‑β (Aβ) plaques, intracellular tau aggregates and neurodegeneration. Lecanemab and donanemab, are the first disease-modifying antibodies available for early Alzheimer's disease. Both reduce Aβ plaques and slow cognitive decline. Lecanemab targets soluble protofibrils and donanemab targets fibrillar Aβ. The primary side effect is amyloid-related imaging abnormalities (ARIA), which can occur as edema (ARIA-E) or hemorrhages (ARIA-H). The risk is higher in APOE4 homozygotes, anticoagulation or cerebrovascular diseases. Therefore, during treatment a regular monitoring with magnetic resonance imaging (MRI) is mandatory.

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کلیدواژه‌ها

Amyloid βDementiaDonanemabLecanemabMild cognitive impairment
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