PubMed چکیده/رکورد

Invasive Physiologic Assessment: From Fractional Flow Reserve to Full Physiology and Beyond.

Jacopo Farina, Simone Biscaglia, Gianluca Campo• 2026• Cardiology clinics
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چکیده اصلی

Over 3 decades, invasive coronary physiology has evolved into a cornerstone of cardiovascular care. Fractional flow reserve (FFR) enabled lesion-specific assessment of epicardial stenoses, improving percutaneous coronary intervention (PCI) selection beyond angiography. Recognition of ischemia without obstructive disease expanded its role, with contemporary testing integrating adenosine-based flow assessment and acetylcholine-based evaluation of endothelial and vasomotor function, allowing identification of angina with nonobstructive coronary arteries endotypes, and tailored therapy. Physiologic pullback and post-PCI indices support procedural planning. Emerging tools, including angiography-derived indices, FFR-computed tomography, and optical coherence tomography (OCT)-based virtual flow reserve, are extending physiology-guided care toward noninvasive assessment and precision cardiovascular intervention.

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کلیدواژه‌ها

ANOCA (angina with nonobstructive coronary arteries)Coronary function testingCoronary physiologyFractional flow reserve (FFR)Physiology-guided PCI
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