PubMed2026
Biodegradable polylactic acid-based microspheres have been widely used in biomedical applications such as drug delivery and tissue engineering, however, most of the microspheres typically possess simple surface structures, lacking bioactivity and the ability to promote cell adhesion. Our group previously synthesized poly (L-lactic acid) magnesium-doped microspheres (PMg) with immunomodulatory and osteogenic potential. However, several …
PubMed2026
Precise regulation of vascular endothelial growth factor (VEGF) delivery is essential for angiogenesis-oriented tissue engineering, because excessive or poorly controlled VEGF exposure may lead to abnormal and immature vascular structures. In this study, aligned core-shell fibrous threads loaded with deoxycholic acid-modified branched polyethylenimine/plasmid encoding VEGF (bPEI1.8-DA/plasmids encoding vascular endothelial growth facto…
PubMed2026
Esophageal reconstruction is one of the most challenging procedures in gastrointestinal surgery. While conventional therapeutic approaches, such as gastric pull-up and intestinal interposition, can restore continuity, they often fail to replicate native physiology. This limitation frequently leads to long-term complications, including dysphagia, stricture, and reflux, which can significantly affect the patients' quality of life. Tissue…
PubMed2026
The purpose of this review is to summarize the most influential and conceptually significant publications from the past 2 years, including substantial 2026 publications, and to identify emerging directions likely to shape xenotransplantation and regenerative medicine in the near future. Advances in artificial intelligence (AI) now support more structured anticipation of future developments by integrating patterns across experimental, c…