PubMed چکیده/رکورد

Streamlining mavacamten treatment pathways: clinical and economic evaluation of point-of-care CYP2C19 genotyping.

Anisha Patel, Jessica Gadsby, Harshil Dhutia, Helen Knight, Julian Barwell, Hussain Mulla• 2026• The International journal of pharmacy practice

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پخش حرفه‌ای فارسی و انگلیسی

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چکیده اصلی

OBJECTIVES: To evaluate whether point-of-care (POC) CYP2C19 genotyping streamlines mavacamten initiation. METHODS: Pre-post service evaluation in a tertiary cardiology service; 10 consecutive patients underwent parallel laboratory and POC genotyping. Outcomes were concordance, turnaround time, number of appointments, patient preference, and costs. KEY FINDINGS: Concordance was 100%. Laboratory turnaround was 10 days; POC run time 63 min. Appointments fell from three to one. Costs decreased by £245.76 per patient for the health service and £118 for patients; break-even was about 3-4 patients per year. CONCLUSIONS: POC genotyping is feasible, improves efficiency and experience, and offers a credible economic case.

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کلیدواژه‌ها

clinical pharmacyclinical practicedelivery of carehealth economicsmedicines managementpharmaceutical careresearch method

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