PubMed چکیده/رکورد

An unanchored matching-adjusted indirect comparison of the efficacy of zanubrutinib versus ibrutinib for the treatment of relapsed/refractory mantle-cell lymphoma.

Toby A Eyre, Leyla Mohseninejad, Lianne Barnieh, Kaijun Wang, Yiran He, Keri Yang, Rhys Williams, Bijal D Shah• 2026• Journal of medical economics

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چکیده اصلی

OBJECTIVE: No head-to-head trials have compared the efficacy of zanubrutinib versus ibrutinib in relapsed/refractory mantle-cell lymphoma (R/R MCL). METHODS: Following a systematic literature review, individual patient data from trials of zanubrutinib (n = 118) and aggregate data from a pooled analysis of ibrutinib trials (n = 370) were analyzed using an unanchored matching-adjusted indirect comparison (MAIC). RESULTS: After matching selected covariates, statistically significant differences were observed with zanubrutinib versus ibrutinib for progression-free survival (hazard ratio [HR] = 0.63; 95% confidence interval [CI] 0.46-0.87, p = .0044) and overall survival (HR, 0.46; 95% CI 0.30-0.71, p = .0005). CONCLUSION: These MAIC analyses demonstrate that zanubrutinib may be more effective than ibrutinib at delaying disease progression and death in R/R MCL.

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کلیدواژه‌ها

I00L65Zanubrutinibibrutinibmantle-cell lymphomamatching-adjusted indirect comparisonsystematic literature review

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