PubMed چکیده/رکورد

Photothermal Pulse Output-Nanomachines for Enhanced Cuproptosis in Tumor Cells.

Yu Dong, Luzhe Zhang, Lin Zhang, Rui Gao, Zirui Zhang, Yongsheng Du, Weiwei Qiao, Fei Tong• 2026• ACS applied bio materials

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چکیده اصلی

Cu@MSNs@ICG nanomachines possess a unique architecture featuring copper deposited on mesoporous silica nanoparticles (MSNs) with indocyanine green (ICG) modification, enabling excellent photothermal pulse output under NIR-II irradiation. Upon 1064 nm illumination, these nanomachines undergo directional self-thermophoretic motion. In the tumor cell microenvironment, the photothermal pulse output drives self-thermophoretic locomotion, simultaneously facilitating photothermal therapy and cuproptosis. This biocompatible, photothermally activated nanomachine system offers a promising platform for synergistic tumor cell therapy.

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کلیدواژه‌ها

NIR-II photothermal controlcuproptosisphotothermal pulse outputself-thermophoretic nanomachinestumor cell

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