PubMed چکیده/رکورد

Localized stiffness programming enables tunable spatial control of vascular density in 3D hydrogels.

He Li, Fiona Louis, Oju Jeon, Eben Alsberg, Michiya Matsusaki• 2026• Chemical communications (Cambridge, England)

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چکیده اصلی

We report an in situ light-mediated reinforcement strategy for spatial microvascular patterning. Laser-patterned stiff zones in AlgMA/fibrin hydrogels suppress capillary formation by >81%. A linear stiffness-density relationship (R2 > 0.78) enables predictable engineering of heterogeneous tissue architecture.

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